Emotional Pain Associated With ED

Performance anxiety is a very real issue for most men at one time or another. The fear of not being able to perform adequately, dissatisfaction with penis size, and self-consciousness about body appearance can all lead to the very thing that most men wish to avoid - failure to get an erection. ........Percentage of time Viagra use results in sex: 66%
Percentage of Viagra users who have sex at least once after using the drug for a few weeks: 83% Average duration of erection with 100 mg of Viagra and 20 minutes of sex videos, among men with erectile dysfunction: 1 minute
So use the drug properly under prescription and feel better and much more comfortable than ever before. Read More>>

Arginine, Is This Natural Viagra?

Recent studies have indicated that the dietary supplement L-Arginine works in your body to produce a compound, Nitric Oxide which is used by the male reproductive system to stimulate an erection. The compound, L-Arginine, is a naturally occurring amino acid that is found in our muscle and cell tissue. Although our diets provide a fair amount of this amino acid, dietary supplementation has been shown to be effective in treating low levels of erectile dysfunction.

Subsequently, Arginine seems to be the body’s natural Viagra.
The supplement itself seems to be effective, and vitamin companies are fighting to develop products to exploit its effectiveness. Many nutritional products that now boast treatment of erectile dysfunction contain high levels of Arginine with a myriad of other compoundsRead More>>

Andropause and Erectile Dysfunction

One of the signature symptoms of Andropause is erectile dysfunction (ED). An embarrassing, nerve-wrecking experience, ED is when a male cannot perform for his female partner. In layman’s terms, it is the inability to have an erect penis during sexual activity.

It is the primary issue amongst men in regards to their sex lives. Let’s become acquainted with how a full erection works and why this condition exists.

Men under the influence of Andropause have erectile dysfunction no matter what’s on their mind. Thinking of a nude Playboy centerfold model would likely induce pleasant and sexual thoughts into a man. Sexual thoughts, however detailed or brief they may be, are produced in the brain. After all, the brain is responsible for thinking. These sexual thoughts directly spark nerve signals down through the spinal cord and into the muscles of the penis. These nerves send a flow of blood running through the arteries in the penis while it is in a relaxed state, building pressure.

A man without Andropause can have a constant, steady flow of blood flowing to his penis arteries in a good amount. The more blood that flows down there, the harder and longer your erection will be! When sexual thoughts creep out of your mind and you’re focused on another activity, your penis returns to its relaxed state. We can guess Andropause sufferers are going to have to do something Read More>> 

Do erectile dysfunction drugs causes NAION ?

On July 8, 2005 the FDA ordered warnings be put on the package insert labels of Viagra, Cialis, and Levitra to the effect that some users of these impotence drugs -- or erectile dysfunction (ED) drugs -- have developed NAION, a form of blindness. At the same time, however, the FDA stated that it is impossible at present to know if NAION is a side effect of these ED drugs, or an unrelated medical condition.

NAION is considered one of the most common causes of sudden vision loss in older people, with anywhere from 1,000 to 6,000 cases a year, also NAION is one of the most common causes of unexpected or sudden vision loss in older Americans. So question arises here is what exactly is the NAION? and is there a risk from taking erectile dysfunction drugs?

What is NAION and what is happening inside the body to cause damage to  sight?

NAION is an acronym for Nonarteritic Anterior Ischemic Optic Neuropathy. Well, basically, the optic nerve is a nerve that connects the eye to the brain. That's how we see.

The optic nerve has tiny blood vessels that perfuse it and that's how it gets its blood supply and oxygen for it to function properly.The condition generally starts in one eye and can cause complete blindness if both eyes are affected. Those who have poor eyesight appear to have the highest chances for developing NAION.

Is there a risk from taking erectile dysfunction drugs?

It is possible that in certain individuals the drugs could potentially to  this. For example, one theoretical mechanism -- which hasn't been proven, but it is a possibility -- is we know these drugs in some patients lower the blood pressure overall in the body. And it's possible that as the drug lowers the blood pressure, the blood flow through the tiny blood vessels in the optic nerve may be temporarily diminished. And during that time, the optic nerve may suffer damage. Now, again, this is not a definite mechanism, it's just a proposed possible mechanism for why this may occur.

Read More

Branded Drugs Gain New Hope in Battle Against Generics

11 Aug 2005

More than $80 billion worth of blockbuster drugs faces patent expiration by 2008. These drugs risk losing 80% or greater market share when generic copies hit the market.

Brand managers can retain market share with advance strategic planning and lifecycle management, according to a report, "Combating Generics: Pharmaceutical Brand Defense" [link]), published by pharmaceutical business intelligence firm Cutting Edge Information.

"Combating Generics: Pharmaceutical Brand Defense" ([link]) examines a variety of commercialization and lifecycle management strategies that enable product management teams to retain market share even as generic competitors launch. Each strategy -- including authorized generics, Rx-to-OTC switching, developing franchise and line extensions, and market-crossover strategies -- is explored in detail through featured industry case studies. The report examines both successful and unsuccessful examples of patent and product defense in the face of generic competition.

"With the industry developing fewer blockbuster drugs today, it is of grave importance that pharmaceutical companies protect those drugs whose revenue streams will enable them to keep developing new medicines over the next decade," says Jon Hess, senior analyst at Cutting Edge Information.

"This means brand teams must anticipate generic competition, plan way in advance, and develop a flexible strategy to deal with any scenario."

According to Hess, brand teams and product managers must consider a variety of defensive and proactive strategies to retain market share when generics come into play. "Planning years in advance and knowing which course of action to take when presented with a unique scenario is critical," Hess says.

For example, AstraZeneca retained -- and even grew -- its gastrointestinal franchise when its blockbuster Prilosec encountered generic competition. The company developed and launched a next-generation line extension, Nexium, in time to switch patients to the improved treatment, thereby growing franchise sales by nearly 10% from $6 billion in 2001 to $6.6 billion in 2002.

"Combating Generics: Pharmaceutical Brand Defense," available at [link], includes more than 250 metrics on generics- defense lifecycle management planning and execution, budgets allocated for franchise and line extension R&D, staffing resources dedicated to combating generics, and more.

To download a free summary of this 190-page report, visit [link]. For more information or to learn about other Cutting Edge Information research, contact Jon Hess at jon_hess@cuttingedgeinfo.com or call +1-919-403-6583.

Cutting Edge Information
[link]
[link]

Source:MedicalNewsToday.com

Cause of diabetes-related erectile dysfunction is clarified by Johns Hopkins researchers

10 Aug 2005

A new study from the Brady Urological Institute at Johns Hopkins suggests an over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men.

Researchers have found that one particular simple sugar, present in increased levels in diabetics, interferes with the chain of events needed to achieve and maintain erection and can lead to permanent penile impairment over time. The results, which have implications for new types of erectile dysfunction treatments targeting this mechanism of erection, are described in the August 16 issue of the Proceedings of the National Academy of Sciences.

Previous research had shown that diabetic erectile dysfunction was partially due to an interruption in an enzyme that starts the chain of vascular events leading to an erection. The Hopkins team suspected O-GlcNAc, a blood sugar present in hyperglycemic (high blood sugar) circumstances, to be that interrupting factor.

"We were interested to determine whether high glucose in mellitus modifies the endothelial nitric oxide synthase (eNOS) enzyme, which is responsible for the achievement and maintenance of erection," says Biljana Musicki, Ph.D., lead investigator of the study and a research associate in the Brady Urological Institute.

Erectile dysfunction is a common problem for more than half of men with diabetes. Musicki says that an estimated "50 percent to 75 percent of diabetic men have erectile dysfunction to some degree, [a rate] about threefold higher than in non-diabetic men." This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra.

The study examined rats with type 1 mellitus as well as the overall mechanism of erection. "Erection begins when a sexual stimulus activates the enzyme neuronal nitric oxide synthase (nNOS) that causes short-term release of nitric oxide (NO) at the nerve endings in the penis," Musicki explains.Read More>>

NEW YORK, Aug 4 (Reuters) - Icos Corp. (ICOS.O: Quote, Profile, Research) on Thursday reported a smaller quarterly loss as growing sales of Cialis, the erectile dysfunction drug it shares with Eli Lilly and Co. (LLY.N: Quote, Profile, Research), helped offset marketing costs.

The biotechnology company posted a net loss of $22.6 million, or 35 cents per share, compared with a loss of $51.9 million, or 82 cents a share, a year ago.

Analysts on average expected a loss of 38 cents per share, according to Reuters Estimates.

Bothell, Washington-based Icos said it expects its full-year net loss to be $1.20 to $1.28 per share.

The company forecast 2005 worldwide Cialis sales of $775 million and said it expects selling, general and administrative costs to decline in the second half of the year.

Sales of Cialis, the Viagra rival that boasts effectiveness for up to 36 hours, rose 39 percent to $190.9 million for the quarter.

Icos revenue for the second quarter was $18.1 million, up from $17.9 million a year ago.

Marketing costs rose to $10.5 million, from $10.1 million a year ago.

Source:REUTERS

FDA Scientist Warned of Viagra-Blindness Link: Report

More than a year before news broke that the erectile dysfunction drug Viagra was possibly linked to a rare form of blindness, a U.S. Food and Drug Administration safety officer alerted superiors to the possibility, the Washington Post reported Friday.

The unidentified safety officer had been monitoring adverse event reports and told supervisors in April 2004 that doctors and users should be warned of the findings, she reportedly told congressional investigators. But the FDA issued no public warnings or changes to the drug's label until a scientific journal reported last month of the possible link, the newspaper said.

On Monday, Pfizer issued a statement saying it had no evidence in trials involving 13,000 people of a link between Viagra and a form of blindness called non-arteritic anterior ischemic optic neuropathy (NAION). That followed a report in last month's Journal of Neuro-Ophthalmology, which examined seven cases where men suffered NAION within 36 hours of taking Viagra, the Post said.

The FDA has said it has 38 reports of NAION among Viagra users and five additional reports among users of other impotence drugs, the newspaper said.

In response to the latest report, Consumer's Union, publisher of Consumer Reports, renewed a call for congressional reform of the FDA's drug monitoring system. "The fact the agency responsible for drug safety knew for a year that Viagra was linked to blindness, but did nothing with that information, is a clear indication that the system is broken," a spokesman said in a prepared statement.

Source:HealthDay.com

Pfizer statement regarding Viagra and blindness (NAION)

28 May 2005

A review of 103 Viagra clinical trials involving 13,000 patients found no reports of non-arteritic anterior ischemic optic neuropathy (NAION). Outside of clinical trials, Viagra has been used by more than 23 million men worldwide over the past seven years and reports of visual field loss due to NAION are extremely rare.

There is no evidence showing that NAION occurred more frequently in men taking Viagra than men of similar age and health who did not take Viagra.

NAION is the most common acute optic nerve disease in adults over age 50 and it shares a number of common risk factors with erectile dysfunction: age over 50, high blood pressure, high cholesterol, . Most of the reported cases in which NAION has occurred in men taking Viagra have involved patients with underlying anatomic or vascular risk factors associated with the development of NAION.

Pfizer is in discussions with the Food and Drug Administration to update the Viagra label to reflect these rare ocular occurrences.

Viagra has a strong safety profile and remains an effective medication that benefits millions of patients.

Viagra remains the market-leading ED medicine, with recent data showing more patients switching back to Viagra after trying our competitors than ever before.

http://www.pfizer.com" title="http://www.pfizer.com" target="_blank"http://www.pfizer.com

Source:MedicalNewsToday

There are various ways to solve your impotence  problem which includes:
Drug Therapy:

In drug therapy various drugs such as Viagra® ,Kamagra,Cialis® (tadalafil),and Levitra® (vardenafil) are used.
An enzyme cGMP tells smooth muscles that line an artery to relax. When they relax, blood flow increases.
Another enzyme called phosphodiesterase (PDE) deactivates the cGMP. 
PDE5 is an enzyme that found in penis accepts cGMP and breaks it down henec reducing the flow of blood in penis.
Viagra® contains sildenafil citrate a chemial which blocks (PDE),and helps men to sustain erection for long time. 
Cialis® (tadalafil) and Levitra® (vardenafil). 
blocks PDE5 with different chemicals.
Injection therapy:

There are several drugs which can be injected directly into the erectile tissues of the penis to cause an erection. The most commonly used are papaverine (Papaverine hydrochloride), phentolamine (Regitine), and prostaglandin E1 (Caverject, Prostin, or Alpoprostadil), which can be taken singularly or in combination. Erection usually begins within 15 minutes and may last several hours.

Penile injection therapy involves injecting a single drug or a combination of drugs into the side of the penis. This produces a hard erection that can last for one to two hours.These drugs must be used exactly as prescribed by the physician. If not used correctly, the result could be a prolonged erection, called priapism. When priapism occurs, the blood fails to drain from the penis.This can damage the penile tissue and be extremely painful. A person who has a history of substance abuse, therefore, would be a risky candidate for this therapy since its success requires the exact use of the prescribed drug. Penile injections would be a difficult option for an individual with SCI with limited hand function to use on his own.He must have a partner who is willing to learn to give the injections.
Bimix and Trimix are injectables for intracavernosal administration.They refer to any combination of either two or three chemicals. Bimix is often a mixture of papaverine and phentolamine, while Trimix (PPP) would add PGE1.Other cocktails are used, mainly in Europe. These mixtures are not commercially available but must be mixed by a compounding pharmacy.They are generally much cheaper than Caverject or Edex, and tend to minimize aching in the penis or testicles which is a problem in some men with Prostaglandin (PGE-1) alone. A compounding pharmacy is one which will create custom medications on a doctor's prescription; it usually doesn't include the corner drugstore or large chain pharmacies.

For full article visit solutions to your impotence problem

What is Kamagra?
Kamagra is a discreet pill for the treatment of male erectile dysfunction, often called impotence. it is a real breakthrough treatment that can help many man who have erectile dysfunction to get and keep an erection when they are sexually aroused

How does KAMAGRA work?
KAMAGRA increases blood flow to the penis allowing more blood flow into the penis like happened naturally when a man is sexually stimulated With more blood flowing in and less flowing out, the arteries in the penis enlarge resulting in an erection. If this mechanism is not working properly a man has difficulties in having and keeping en erection. Using KAMAGRA a man can respond to sexual stimulation during a sexual encounter and once it is over the erection goes away.

Will KAMAGRA work immediately?
It takes 60 minutes before KAMAGRA starts to work and stays to work for up to 4 hours.

Does KAMAGRA automatically cause an erection?
No. With KAMAGRA, you must be sexually aroused to get an erection. If you take KAMAGRA and are not sexually stimulated, nothing will happen–you won't get an erection just by taking the pill. KAMAGRA is not a hormone. It is not an aphrodisiac. It's a prescription medication that can improve the erectile function of most men with erection problems.

How much KAMAGRA can I take?
KAMAGRA comes in different doses (25 mg, 50 mg, and
100 mg). Like many medications, your healthcare provider may have to adjust your initial KAMAGRA dose if it doesn't produce the desired results or you're bothered by side effects. Do not take more KAMAGRA than your healthcare provider prescribes. KAMAGRA can be used up to once a day as needed.

If you are older than 65 years, have a serious liver or kidney problem, or are taking protease inhibitors, such as for the treatment of HIV, your healthcare provider may start you at the lowest (25-mg) dose of KAMAGRA.

How often can I take KAMAGRA?
For most patients, KAMAGRA should be taken once a day as needed. In patients taking certain protease inhibitors (such as for the treatment of HIV), it is recommended to not exceed a maximum single dose of 25 mg of KAMAGRA in a 48-hour period..

Who should not take KAMAGRA?
KAMAGRA is not for newborns, children, or women. Do not let anyone else take your KAMAGRA. KAMAGRA must be used only under a healthcare provider's supervision.

Before you start any treatment with KAMAGRA, be sure to ask your healthcare provider if your heart is healthy enough. If you're a man who uses nitrate drugs, like nitroglycerine, never take KAMAGRA. The combination of KAMAGRA and nitrates can make your blood pressure suddenly drop to unsafe levels. You could get dizzy, faint, or even have a heart attack or stroke. Nitrates are found in many prescription medications that are used to treat angina (chest pain due to heart disease) such as:

Nitroglycerin (sprays, ointments, skin patches or pastes, and tablets that are swallowed or dissolved in the mouth)
Isosorbide mononitrate and isosorbide dinitrate (tablets that are swallowed, chewed, or dissolved in the mouth)
Nitrates are also found in recreational drugs such as amyl nitrate or nitrite ("poppers"). If you are not sure if any of your medications contain nitrates, or if you do not understand what nitrates are, ask your healthcare provider or pharmacist.

What if KAMAGRA doesn't work?
While KAMAGRA is effective in up to 4 of 5 men, it's not effective for everyone. If it doesn't work for you, contact your healthcare provider to discuss other treatment options.

Can I take KAMAGRA with alcohol?
Drinking alcohol can temporarily impair the ability to get an erection. To get the maximum benefit from your medication, you are advised not to drink large amounts of alcohol before taking KAMAGRA

Can I take KAMAGRA after eating?
Yes, but taking KAMAGRA after a high-fat meal (such as a cheeseburger and french fries) may cause the medication to take a little longer to start working.

What are the side effects of KAMAGRA?
Like all medications, KAMAGRA can cause some side effects. These are usually mild and don't last longer than a few hours. Some of these side effects are more likely to occur with higher doses of KAMAGRA. With KAMAGRA, the most common side effects are headache, facial flushing, and upset stomach. KAMAGRA may also briefly cause bluish or blurred vision or sensitivity to light. In the rare event of an erection lasting more than 4 hours, seek immediate medical help..

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